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For example, semaglutide and native GLP-1 promote relatively conventional recycling and internalization, whereas biased agonists like tirzepatide favor sustained receptor retention at the plasma membrane with reduced cytosolic trafficking [48]

The recommended starting dose in patients not currently treated with metformin is 100 mg sitagliptin and 1000 mg metformin HCl extended-release once daily, with gradual dose escalation recommended to reduce gastrointestinal side effects associated with metformin

The right choice depends on what is actually driving your weight gain, which is why a functional medicine workup comes before any prescription

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